Molecular cell biology 7th by lodish pdf

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Share this link with a friend: Instant download and all chapter: They can generate multiple mRNAs. Some signaling molecules are transported long distancflS by the blood; others have more local effects. Which of the following is not a mobile DNA element?

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University of the West of England. Uploaded By mondea. Instant download and all chapter: Linking Concepts and Facts 6.


Which of the following is a typical feature of prokaryotic genes? The chicken lysozyme gene is considered to be a solitary gene because 3.

All the following statements about complex transcription units are true except: They can have multiple poly A sites. They can generate multiple mRNAs. They can generate multiple polypeptides.

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They are common in bacteria. In eukaryotes, tandemly repeated genes encode 5. Which of the following organisms has the greatest amount of DNA per cell? All the following statements about microsatellite DNA are true except: The connection between an activated receptor and a cel- lu l ar response is not direct and generally involves several in- termediate proteins or small molecules.

Co llectively, this chain of intermediates is called a signal transduction path- way because it transduces, or converts, information from one form into another as a signal is relayed from a receptor to its targets.

Some signal transduction pathways contain just two or three intermediates; others can involve over a dozen. Regardless, most pathways contain members of cer- tain classes of signal transduction proteins that have been highly conserved throughout evolution.


In this section, we provide an overview of the major steps in signal transduction, starting with the signaling molecules themselves. We explore the molecular basis for ligand-receptor binding and the chain of events initiated in the target cell by binding of the signal to its receptor, focusing on a few compo- nents that are central to many signal transduction pathways.

Signaling Molecules Can Act Locally or at a Distance Cells respond to many different types of signals-some orig- inating from outside the organism, some internally gener- ated. Those that are generated internally can be described by how they reach their target. Some signaling molecules are transported long distancflS by the blood; others have more local effects. In animals, signaling by extracellular molecules can be classified into three types-endocrine, paracrine, or autocrine-based on the distance over which the signal acts Figure a-c.

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In addition, certain membrane-bound pro- teins on one cell can directly signal an adjacent cell. In endocrine signaling, the signaling molecules are synthe- sized and secreted by signaling cells for example, those found in endocrine glands , transported through the circulatory sys- tem of the organism, and tinally act on target cells Jistant from their site of synthesis.

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The term hormone generally re- fers to signaling molecules that mediate endocrine signaling.